Which gene makes instructions for making the haemoglobin protein?

Which gene makes instructions for making the haemoglobin protein?

• A. HBB gene
• B. HFE gene
• C. HBA1 gene
• D. CFTR gene

Answer: (A)

Haemoglobin is built from globin protein subunits, specifically alpha and beta chains. The instructions to make the beta-globin part come from the HBB gene, so this gene directly encodes the beta chain of haemoglobin. The alpha chains are encoded by HBA1 (and HBA2). The other two genes encode a protein involved in iron regulation and another protein that acts as a chloride channel, not haemoglobin. So the gene that makes instructions for haemoglobin protein is the one that encodes beta-globin.

Haemoglobin is built from globin protein subunits, specifically alpha and beta chains. The instructions to make the beta-globin part come from the HBB gene, so this gene directly encodes the beta chain of haemoglobin. The alpha chains are encoded by HBA1 (and HBA2). The other two genes encode a protein involved in iron regulation and another protein that acts as a chloride channel, not haemoglobin. So the gene that makes instructions for haemoglobin protein is the one that encodes beta-globin.